Taste Masking of Propiverine Hydrochloride by Conversion to Its Free Base

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Taste masking of propiverine hydrochloride by conversion to its free base.

The aim of the present study was to mask the bitterness of propiverine hydrochloride (P-4) by converting it to propiverine free base. Fine granules comprising the free base, which was converted from P-4 by desalination, were prepared. By using Fourier transform infrared spectroscopy, thermogravimetry-differential thermal analysis, and powder X-ray diffraction spectra, we confirmed that P-4 had ...

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 2012

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.c12-00206